The anticancer effect of edible fungi mainly comes from the polysaccharide body in edible fungus, although this kind of compound has no direct killing effect on tumor cells, it can stimulate the formation of antibody, improve and adjust the defense ability of organism.
In addition, edible fungi can reduce the incidence of tumor induced by some substances, and for a variety of Chemotherapeutic drugs have synergistic effects. Sasaki ET (1971) found that the polysaccharide G-2 isolated from the tree tongue can inhibit the growth of S-180 sarcoma in mice. Li Xusheng and so on, Ganoderma lucidum mycelium Extract (GLP) of c3h mice in the muscle fiber malignant tumor inhibition, but also to the tumor cell lung metastasis lesions have inhibitory effect. The antitumor effect of Tremella polysaccharide was first seen in Ukai (1972), and it was found that Tremella polysaccharide had obvious inhibitory effect on rat S-180 sarcoma. Zhou ET (1987) found that intraperitoneal injection of tremella polysaccharide can significantly inhibit the growth of Ehrlich ascites carcinoma in mice, and significantly inhibit the DNA synthesis rate of ascites cells. Chihara ET (1969) first found that the hot water extracts of mushrooms can resist the growth of mouse S-180 sarcoma, from which the mushroom polysaccharide (lentinan), not only to resist tumor growth but also to prevent chemical and viral tumor-induced carcinogenic effects. In Japan since ancient times, chestnut mushroom as a wild herb for the treatment of stomach cancer, esophagus cancer, breast cancer, chestnut mushroom inhibition is mainly β-d-dextran. In addition, chestnut mushroom is rich in organic selenium, can be used as selenium supplement food, if long-term consumption, can almost prevent all canceration. Krestin polysaccharide (PSK, commodity name Krestin), Krestin polysaccharide peptide (PSP), Poria polysaccharide and Carboxymethyl poria Cocos polysaccharide (Schizophyllan), polysaccharide of polysaccharide, etc. also have anti-tumor effects, which inhibit the transplanted tumor of experimental animals.
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